Thursday, 8 September

12:45 – 13:00	Opening Remarks	Grand Ballroom CD
13:00 – 14:00	Plenary Lectures Systems biology, transformational technologies and the emergence of proactive P4 medicine Leroy Hood Systems biology approaches to viral pathogenesis and immunity: where are Google and IBM? Michael Katze	Grand Ballroom CD
14:00 – 15:30	Session 1: Host Genetics and Host Responses Session Chairs: Jordan Feld and Masao Honda	Grand Ballroom CD
14:00	Liver cell-specific expression phenotypes and hepatitis C virus treatment responses: phenotype outperforms IL28B genotype Jordan J. Feld, Limin Chen, Maha Guindi, Sandra Fischer, E. Jenny Heathcote, Ivan Borozan, Xiangdong Liu, Aled Edwards, Nazia Selzner, Katherine Siminovitch, Ian McGilvray	O1.01
14:15	Association of TLR7 rs179008 gene variants with hepatic IL-29/IFN-lambda1 and IFN-lambda receptor expression in chronic hepatitis C Sabine Mihm, Eva Askar, Giuliano Ramadori	O1.02
14:30	NK inhibitory receptor expression associated with treatment failure and IL-28B genotype in patients with chronic hepatitis C Hugo Rosen, Lucy Golden	O1.03
14:45	High hepatic IFNλ-R1 receptor levels are associated with HCV RNA clearance in IL28B genotype CC HCV patients Jie Chen, Thomas Urban, Yuhong Zhang, Jeremie Guedj, Alan Perelson, Daryl Lau	O1.04
15:00	Liver gene expression signature of mild fibrosis in chronic hepatitis C Aurélie Ducès, Martine Lapalus, Ivan Bièche, Bénédicte Jardin-Watelet, Eve Dupas, Simon De Muynck, Isabelle Molina, Nadine Lambert, Bérénice Sallenave, Emilie Nicolas, Emilie Estrabaud, Nathalie Julian, Michelle Martinot-Peignoux, Olivier Lada, Valérie Paradis, Dominique Valla, Pierre Bedossa, Daniel Laune, Michel Vidaud, Patrick Marcellin, Tarik Asselah	O1.05
15:15	Gene signatures associated with liver disease progression in HCV patients following liver transplantation Angela Rasmussen, Nathan Susnow, Alexei Krasnoselsky, Sujay Datta, Craig Magaret, Matthew Yeh, Deborah Diamond, Sean Proll, Sharon Lederer, Kathie Walters, Robert Carithers Jr, Steven Self, Michael Katze	O1.06
15:30 – 16:00	Refreshment Break	Grand Ballroom Pre-Function Area
16:00 – 16:30	Plenary Lecture The Spectrum of HCV Disease Norah Terrault	Grand Ballroom CD
16:30 – 18:00	Session 2: Pathogenesis Session Chairs: Chihiro Morishima and Christopher Richardson	Grand Ballroom CD
16:30	Laser capture microdissection reveals that fibrosis in chronic HCV infection is associated with a loss of immune, metabolic,and redox functions Supriya Munshaw, Hyon S. Hwang, Michael Torbenson, David L. Thomas, Stuart C. Ray, Ashwin Balagopal	O2.01
16:45	HCV may trigger hepatic carcinogenesis through modulation of c-Myc oncogene expression, enhancing oxidative stress and DNA damage Martin Higgs, Herve Lerat, Jean-Michel Pawlotsky	O2.02
17:00	TLR4-Nanog stemness pathway in HCV-induced cancer stem cells confers resistance to TGF-β-mediated tumor suppression through YAP1 and IGF2BP3-AKT-mTOR Keigo Machida, Chia-Lin Chen, Jian-Chang Liu, Claudine Kashiwabara, Douglas Feldman, Samuel French, Jeong Hyeongnam, Linda Sher, Hidekazu Tsukamoto	O2.03
17:15	Infection of SCID/Alb-uPA mice by HCV leads to liver damage, apoptosis and fibrosis Michael Joyce, Kinola Williams, Gerald Lachance, Ran Chen, Lin-Fu Zhu, Sue-Ellen Lamb, Deborah Burshtyn, D. Lorne Tyrrell	O2.04
17:30	Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in mice Yuri Kasama, Satoshi Sekiguchi, Michinori Kohara, Kyoko Tsukiyama-Kohara	O2.05
17:45	Hepatitis C virus stabilization of hypoxia inducible factor-1α promotes epithelial to mesenchymal transition Garrick Wilson, Gary Reynolds, Claire Brimacombe, Ke Hu, Maria Simoes, Margaret Ashcroft, Peter Balfe, Stefan Hubscher, Jane McKeating	O2.06
18:00 – 20:00	Welcome Reception	Grand Ballroom AB