Sunday, 11 September   08:00 – 08:30 Plenary Lecture A new era in HCV antiviral therapy Donald Jensen Grand Ballroom CD 08:30 – 10:30 Session 8a: Antiviral Therapy Sponsored by Session Chairs: Jeffrey Glenn and Matthias Gotte Grand Ballroom CD 08:30 Targeting lipid droplet biogenesis for the discovery of novel anti-HCV drugs Andrea Olmstead, Francois Jean O8.01 08:45 HCV NS5A: NMR analyses of its interactions with NS5B and cyclophilin A and molecular characterization of a cyclophilin inhibitor-resistance mutation Xavier Hanoulle, Isabelle Huvent, Claire Rosnoblet, Dries Verdegem, Marie Dujardin, Aurélie Badillo, Lotte Coelmont, Bernd Fritzinger, Jean-Michel Wieruszeski, Isabelle Landrieu, Johan Neyts, Ralf Bartenschlager, François Penin, Guy Lippens O8.02 09:00 Solution structure of monomeric hepatitis C virus (HCV) p7 in a native, drug binding, hairpin conformation Toshana Foster, Arnout Kalverda, Gary Thompson, Joseph Thompson, Arwen Pearson, Richard Foster, Steven Homans, Mark Harris, Stephen Griffin O8.03 09:15 Structure and dynamics of membrane-associated p7 by NMR spectroscopy Lindsay Dawson O8.04 09:30 Deciphering conformational variability of the hepatitis C virus polymerase (genotype 1) in complex with inhibitors Célia Caillet-Saguy, Philip C. Simister, Stéphane Bressanelli O8.05 09:45 Elimination of HCVcc using recombinant AAV vector-mediated delivery of anti-HCV miRNAs Xiao Yang, Shangzhen Zhou, Guangxiang Luo, Linda Couto O8.06 10:00 Phosphatidylinositol 4-kinase IIIα is targeted by 4-aminoquinazoline compounds with anti-HCV activity Raffaele De Francesco, Annalisa Bianco, Reinaldo Alvarez, Simone Fenu, Veronica Reghellin, Massimiliano Pagani, Sergio Abrignani, Petra Neddermann O8.07 10:15 The non-nucleoside inhibitor tegobuvir utilizes a novel mechanism of action to inhibit HCV NS5b polymerase function Christy M. Hebner, Bin Han, Katherine M. Brendza, Michelle Nash, Maisoun Sulfab, Yang Tian, Magdeleine Hung, Wanchi Fung, Randy Vivian, James Trenkle, Kyla Bjornson, Steven Bondy, Xiaohong Liu, Swami Swaminathan, John Link, Johan Neyts, Roman Sakowicz, Uli Schmitz, Weidong Zhong O8.08 10:30 – 11:00 Refreshment Break Grand Ballroom Pre-Function Area 11:00 – 13:00 Session 8b: Antiviral Therapy Sponsored by Session Chairs: Daniel Lamarre and Jean-Michel Pawlotsky Grand Ballroom CD 11:00 NS5A dimerization: a potential drug target? Precious Lim, Udayan Chatterji, Dan Cordek, Craig Cameron, Paul Targett-Adams, Kai Lin, Philippe Gallay O8.09 11:15 The green tea polyphenol epigallocatechin-3-gallate (EGCG) inhibits hepatitis C virus (HCV) entry Sandra Ciesek, Thomas von Hahn, Luis M. Schang, Martina Friesland, Michael P. Manns, Michael Ott, Heiner Wedemeyer, Philip Meuleman, Thomas Pietschmann, Eike Steinmann O8.10 11:30 Marked synergy of entry inhibitors and interferon-alfa or direct acting antivirals on the inhibition of hepatitis C virus infection Fei Xiao, Isabel Fofana, Joachim Lupberger, Pieter Leyssen, Johan Neyts, Mirjam B. Zeisel, Thomas F. Baumert O8.11 11:45 The RAFIs aUY11 and dUY11 inhibit infectivity of HCV and other enveloped viruses by preventing fusion of viral and cellular membranes Che C. Colpitts, Alexey V. Ustinov, Vladimir A. Korshun, Luis M. Schang O8.12 12:00 Identification and functional analysis of small molecules inhibiting the late step of hepatitis C virus life cycle Koichi Watashi, Nanako Uchida, Ryosuke Suzuki, Hideki Aizaki, Takaji Wakita O8.13 12:15 Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes Kyoko Tsukiyama-Kohara, Takashi Takano, Yuichi Hirata, Yuko Tokunaga, Chise Tateno, Masayuki Sudo, Michinori Kohara O8.14 12:30 The impact of calcineurin inhibitors on HCV replication in a chimeric mouse model of HCV infection Norman Kneteman, Jamie Lewis, Donna Douglas, Mahra Nourbakhsh, Lorne Tyrrell, Garry Lund O8.15 12:45 PPARα agonist WY14643 improves the antiviral effect of interferon against hepatitis C virus Scott Read, Jacob George, Mark Douglas O8.16 13:00 – 14:30 Lunch Grand Ballroom AB 14:30 – 15:00 Plenary Lecture Virus-Host Interactions Markus Heim Grand Ballroom CD 15:00 – 17:00 Session 9a: Virus-Host Interactions Session Chairs: Michael Beard & Ratna Ray Grand Ballroom CD 15:00 A mouse model for hepatitis C virus infection and immunity Marcus Dorner, Joshua Horwitz, Alexander Vogt, Kathy Mu, Gisa Gerold, Charles Rice, Alexander Ploss O9.01 15:15 Hepatitic C virus infection of differentiated human hepatocytes derived from embryonic and induced pluripotent stem cells Xianfang Wu, Jason Robotham, Hongying Deng, Hengli Tang O9.02 15:30 Molecular determinants and dynamics of hepatitis C virus secretion Kelly Coller, Nicholas Heaton, Kristi Berger, Jacob Cooper, Jessica Saunders, Glenn Randall O9.03 15:45 Impaired signaling and function induced in plasmacytoid dendritic cells exposed to HCV Jonathan Florentin, Clélia Dental, Besma Aouar, Françoise Gondois-Rey, David Durantel, Thomas F. Baumert, Daniel Olive, Ivan Hirsch, Ruzena Stranska O9.04 16:00 HCV infection leads to stimulation of LDL receptor expression Aleem Siddiqui, Huihui Tang, Gulam Syed, Tarek Hassanein O9.05 16:15 Inflammasome activation by hepatitis C virus Amina Negash, Hilario Ramos, Michael Gale Jr. O9.06 16:30 HCV directly stimulates the production of the inflammasome-associated cytokine IL-18 in cells of the monocyte lineage Michael Chattergoon, Erik Orberg, Jordana Levine, Andrea Cox O9.07 16:45 miR-122 stabilizes hepatitis C virus RNA by an Ago2-dependent mechanism Tetsuro Shimakami, Daisuke Yamane, Rohit Jangra, Brian Kempf, Carolyn Spaniel, David Barton, Stanley Lemon O9.08 18:00 – 23:30 Symposium Gala Museum of Flight