Saturday, 10 September   08:00 – 08:30 Plenary Lecture Liver disease in HCV infection: from cell death to inflammation to fibrosis with a few things in between Jacqueline Maher Grand Ballroom CD 08:30 – 10:30 Session 7a: Virology: Entry Sponsored by Session Chairs: Matt Evans and Thomas Pietschmann Grand Ballroom CD 08:30 Visualizing HCV-receptor dynamics at the cell surface Helen Harris, Caroline Clerté, Amy Barnes, Margaret Goodall, Ke Hu, Garrick Wilson, Christine Thumann, Patrice Rassam, Ragai Mitry, Anil Dhawan, Thomas Baumert, Pierre Milhiet, Jane McKeating O7.01 08:45 Viral and cellular determinants of HCV cell-to-cell spread Maria Teresa Catanese, Joana Loureiro, Christopher T. Jones, Timothy Sheahan, Alfredo Nicosia, Charles M. Rice O7.02 09:00 High-resolution imaging studies of HCV entry pathways Janice Elaine Silverman, Zongyi Hu, T. Jake Liang O7.03 09:15 EGF promotes hepatitis C virus entry by activating EGFR phosphorylation at Y1086 and the Ras/MAP kinase signaling pathway Laetitia Zona, Joachim Lupberger, Christine Thumann, Benoit Fischer, Laure Froidevaux, Jonathan Florentin, François Duong, Michelle J. Farquhar, Mirjam B. Zeisel, Jacques A. Nunès, Ivan Hirsch, Laurent Brino, Jane A. McKeating, Thomas F. Baumert O7.04 09:30 The Niemann-Pick C1-Like 1 cholesterol absorption receptor: a novel hepatitis C virus entry factor and therapeutic target Bruno Sainz, Naina Barretto, Danyelle Martin, Nobuhiko Hiraga, Michio Imamura, Xuemei Yu, Kazuaki Chayama, Waddah Alrefai, Susan Uprichard O7.05 09:45 The SLAM family receptor CD229: a key role in hepatitis C virus binding and infection Flora Cartier, Rémy Nyga, Christèle Ossart, Luciane Lamotte, Kaïss Lassoued, Hicham Bouhlal O7.06 10:00 HCV entry inhibitors arbidol and silibinin hinder early steps of viral trafficking as revealed by single particle tracking analysis Julie Blaising, Pierre Levy, Elodie Teissier, Jean-Pierre Lavergne, Eve-Isabelle Pecheur O7.07 10:15 Genotype dependent usage of CLDN-family members as HCV entry receptors Sibylle Haid, Christina Grethe, Thomas Pietschmann O7.08 10:30 – 11:00 Refreshment Break Grand Ballroom Pre-Function Area 11:00 – 13:00 Session 7b: Virology: Replication Sponsored by Session Chairs: Pablo Gastaminza and Volker Lohmann Grand Ballroom CD 11:00 High-resolution profiling HCV genome by combining random insertion mutagenesis with next-generation sequencing Hangfei Qi, Sheng-Yao Su, Zugen Chen, Shu-hwa Chen, Vaithilingaraja Arumugaswami, Stanley Nelson, Chung-yen Lin, Ren Sun O7.09 11:15 The SHAPE of RNA cis-acting replication elements of HCV Andrew Tuplin, Madeleine Struthers, Peter Simmonds, David Evans O7.10 11:30 CREB3L1: a host transcription factor that inhibits proliferation of virus-infected cells Bray Denard, Joachim Seemann, Quiyue Chen, Austin Gay, Hua Huang, Jin Ye O7.11 11:45 Productive homologous and heterologous recombination of HCV RNA in vitro Troels K. H. Scheel, Judith M. Gottwein, Lotte S. Mikkelsen, Jens Bukh O7.12 12:00 Novel infectious clone of HCV 1a strain HCV-RMT efficiently replicate in vitro and in vivo using adaptive mutations Yuko Tokunaga, Masaaki Arai, Asako Nakaya, Yoshimi Tobita, Chise Tateno, Michinori Kohara O7.13 12:15 Mapping the nascent RNA channel of the hepatitis C virus RNA dependent RNA polymerase using mass spectrometry Robert Vaughan, Hui Cai, Jin-Sam You, C. Cheng Kao O7.14 12:30 NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional HCV replication complexes David Paul, Inés Romero-Brey, Jérôme Gouttenoire, Savina Stoitsova, Jacomine Krijnse-Locker, Darius Moradpour, Ralf Bartenschlager O7.15 12:45 Diacylglycerol acyltransferase 1 (DGAT1) functions as a cellular “hub” for HCV NS5A and core proteins Gregory Camus, Eva Herker, Charles Harris, Robert Farese, Melanie Ott O7.16 13:00 – 14:30 Lunch Grand Ballroom AB 14:30 – 16:30 Session 7c: Virology: Assembly Sponsored by Session Chairs: Brett Lindenbach and Susan Uprichard Grand Ballroom CD 14:30 A highly specific genetic interaction between core and NS3 is essential for the production of infectious hepatitis C virus Daniel Jones, Ali Atoom, Rodney Russell O7.17 14:45 Identification of lipid droplet-associated membrane proteins that are involved in HCV production Hideki Aizaki, Yoshihiro Matsumoto, Koji Goto, Koichi Watashi, Ryosuke Suzuki, Masayoshi Fukasawa, Kentaro Hanada, Shigeko Sato, Nobuhiro Takahashi, Yoshiharu Matsuura, Kiyoto Motojima, Tatsuo Miyamura, Tetsuro Suzuki, Takaji Wakita O7.18 15:00 Dynamic trafficking of HCV core protein to and from cellular lipid droplets during virus particle assembly Natalie Counihan, Brett Lindenbach O7.19 15:15 A role for the trans-golgi network in HCV release Mark Harris, Jamel Mankouri, Stephen Griffin O7.20 15:30 Underlying molecular mechanisms of apolipoprotein E in hepatitis C virus life cycle Wei Cun, Guangxiang Luo O7.21 15:45 HCV p7 and NS2 induce the early steps of virus assembly by regulating core localization at the endoplasmic reticulum vs. lipid droplets Bertrand Boson, Ophelia Granio, Ralf Bartenschlager, F. L. Cosset O7.22 16:00 NS4B protein facilitates HCV assembly via genetic interaction with p7 and NS5A proteins Kouacou Konan, David Manna, Qingxia Han O7.23 16:15 Two amino acid exchanges are sufficient to restore pestivirus morphogenesis in the absence of uncleaved NS2-3 Norbert Tautz, Oliver Klemens, Erik Lattwein O7.24 16:30 – 19:00 Poster Session 2 Metropolitan Ballroom